Publications

CamNtech Research Library

CamNtech products have been trusted by specialist researchers for 25 years. Our research library contains peer reviewed publications citing the use of our devices. Filter by product, application, keyword, author or use free text search to locate your area of interest.

Found 219 Results

Older posts

A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania

Rationale Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), a probable key therapeutic mechanism. The anti-inflammatory drug, ebselen, also inhibits IMPase and appears well-tolerated and safe. Objectives To assess the efficacy of adjunctive ebselen in mania […]

Publication Date: September 9, 2020

Prediction of individual differences in circadian adaptation to night work among older adults: application of a mathematical model using individual sleep-wake and light exposure data

Circadian misalignment remains a distinct challenge for night shift workers. Variability in individual sleep-wake/light-dark patterns might contribute to individual differences in circadian alignment in night shift workers. In this simulation study, we compared the predicted phase shift from a mathematical model of the effect of light on the human circadian pacemaker to the observed melatonin […]

Publication Date: September 6, 2020

Multiple sclerosis-related fatigue: the role of impaired corticospinal responses and heightened exercise fatigability

It is unclear whether motor fatigability and perceived fatigue share a common pathophysiology in people with multiple sclerosis (PwMS). This cross-sectional investigation explored the relationship between the mechanisms of motor fatigability from cycling and fatigue severity in PwMS. Thirteen highly fatigued (HF) and thirteen non-fatigued (LF) PwMS, and thirteen healthy controls (CON) completed a step-test […]

Publication Date: September 2, 2020

An Automatic Estimation of the Rest-Interval for MotionWatch8© Using Uniaxial Movement and Lux Data

Poor sleep is linked with chronic conditions common in older adults, including diabetes, heart disease, and dementia. Valid and reliable field methods to objectively measure sleep are thus greatly needed to examine how poor sleep impacts older adults. Wrist-worn actigraphy (WWA) is a common objective measure of sleep that uses motion and illuminance data to […]

Publication Date: August 24, 2020

Binocular Vision, Visual Function, and Pupil Dynamics in People Living With Dementia and Their Relation to the Rate of Cognitive Decline and Structural Changes Within the Brain: Protocol for an Observational Study

Background: Visual impairment is a common comorbidity in people living with dementia. Addressing sources of visual difficulties can have a significant impact on the quality of life for people living with dementia and their caregivers. Depth perception problems are purportedly common in dementia and also contribute to falls, visuomotor task difficulties, and poorer psychosocial well-being. […]

Publication Date: August 10, 2020

Local increases in sleep-like activity predict the occurrence of emotion suppression failures

Emotion self-regulation relies both on cognitive and behavioral strategies implemented to modulate the subjective experience and/or the behavioral expression of a given emotion. While it is known that a network encompassing fronto-cingulate and parietal brain areas is engaged during successful emotion regulation, the functional mechanisms underlying failures in emotion suppression are still unclear. In order […]

Publication Date: August 5, 2020

Reduced Neuromuscular Performance in Night Shift Orthopedic Nurses: New Insights From a Combined Electromyographic and Force Signals Approach

The effect of sleep–wake rhythm disruption on neuromuscular control and muscle fatigue has received little attention. Because nurse shift work is so varied, including overnight duty, rotating shift schedules, early awakening, and interrupted nocturnal sleep, it offers an interesting model to study this paradigm. It has been investigated so far using only subjective markers. A […]

Publication Date: June 30, 2020

The clinical relevance of early identification and treatment of sleep disorders in mental health care: protocol of a randomized control trial

Background Sleep disorders are a risk factor for developing a variety of mental disorders, have a negative impact on their remission rates and increase the risk of relapse. Early identification and treatment of sleep disorders is therefore of paramount importance. Unfortunately, in mental health care sleep disorders are often poorly recognized and specific treatment frequently […]

Publication Date: June 24, 2020

Disturbances of Continuous Sleep and Circadian Rhythms Account for Behavioral Difficulties in Children with Autism Spectrum Disorder

Sleep disorders are among the most common comorbidities in children with Autism Spectrum Disorder (ASD), and subjectively defined sleep disturbances have been related to ASD symptom severity. However, no study has investigated the differential impact of objectively measured sleep and circadian rhythm disturbances on behavioral difficulties in this population. Fifty-two children with ASD aged 3–10 […]

Publication Date: June 24, 2020

Using Mobile Electroencephalography and Actigraphy to Diagnose Attention-Deficit/Hyperactivity Disorder: Case-Control Comparison Study

Background: Children with attention-deficit/hyperactivity disorder (ADHD), a neurobehavioral disorder, display behaviors of inattention, hyperactivity, or impulsivity, which can affect their ability to learn and establish proper family and social relationships. Various tools are currently used by child and adolescent psychiatric clinics to diagnose, evaluate, and collect information and data. The tools allow professional physicians to […]

Publication Date: June 19, 2020

A pragmatic approach to the comparison of wrist-based cutpoints of physical activity intensity for the MotionWatch8 accelerometer in children

Background A variety of wearable monitors are available for objectively assessing physical activity but there is a lack of established values for the activity intensity of MotionWatch8 (MW8) and a similar lack of studies on comparability across devices. Our study aimed to establish activity intensity cutpoints for the MW8 accelerometer in children, which are necessary […]

Publication Date: June 19, 2020

Toward a Better Understanding of the Reciprocal Relations Between Adolescent Psychological Need Experiences and Sleep

In two diary studies, we examined the reciprocal daily association between the satisfaction and frustration of adolescents’ basic psychological needs and sleep, and the role of stress and fatigue in these associations. In Study 1 (N = 211; 52% female; Mage = 15.86 years, SD = 1.18 years), daily need experiences were unrelated to daily […]

Publication Date: June 19, 2020

Light effects on circadian and homeostatic regulation: alertness increases independent of time awake

Study Objectives To determine how sleepiness and sleep deprivation drive the motivation to engage in different behaviors. Methods We studied the sleepiness of 123 participants who had been randomized to sleep deprivation or normal sleep, and their willingness to engage in a range of everyday behaviors. Results Self-reported sleepiness was a strong predictor of the […]

Publication Date: June 6, 2020

Early manifestation of sleep problems in toddlers with Williams Syndrome using a mixed method longitudinal approach

Children with neurodevelopmental disorders commonly experience sleep problems. Williams Syndrome (WS), a rare genetic disorder characterised by a complex, uneven cognitive profile, is no exception. Compared with children with typical development (TD), school-aged children with WS experience significant sleep disruption: shorter sleep duration, more night wakings, greater bedtime resistance and excessive daytime tiredness. In children […]

Publication Date: June 3, 2020

Sleep duration, sleep variability, and impairments of visual attention

Attentional networks are sensitive to sleep deprivation. However, variation in attentional performance as a function of normal sleep parameters is understudied. We examined whether attentional performance is influenced by (a) individual differences in sleep duration, (b) sleep duration variability, and/or (c) their interaction. A total of 57 healthy participants (61.4% female, Mage = 32.37 years, SD = 8.68) completed questionnaires, […]

Publication Date: June 1, 2020

Rationale and Study Design of OUTSTEP‐HF: A Randomized Controlled Study to Assess the Effect of Sacubitril/Valsartan and Enalapril on Physical Activity measured by Accelerometry in Patients with Heart Failure with Reduced Ejection Fraction

Aim In PARADIGM‐HF, sacubitril/valsartan demonstrated superiority to enalapril in reducing mortality and morbidity in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Several patient‐centred outcomes like improved physical activity and quality of life (QoL) have been emphasised as important therapy goals in HF management. OUTSTEP‐HF has been designed to evaluate the effects of […]

Publication Date: May 28, 2020

Gateways, Disparities, and Finals Week, Oh My! Translating Sleep Science from the Laboratory to the Classroom

Introduction Organic chemistry can be an insurmountable “gateway” course for otherwise-qualified students in pre-health pathways. Recent data indicate that organic chemistry increases drop-out risk for females and underrepresented minority students (URMs), raising the provocative possibility that sleep disparities are an underrecognized contributor to achievement gaps in gateway STEM courses. Methods In Study 1, 481 students […]

Publication Date: May 27, 2020

Subjective–objective sleep discrepancy in patients with insomnia during and after cognitive behavioural therapy: An actigraphy study

Although patients with insomnia often show a discrepancy between self‐reported and objective sleep parameters, the role of and change in this phenomenon during treatment remain unclear. The present study aimed to assess the effect of cognitive behavioural therapy for insomnia on subjective and objective sleep discrepancy of total sleep time, sleep‐onset latency and wake after […]

Publication Date: May 20, 2020

Effect of a Multimodal Lifestyle Intervention on Sleep and Cognitive Function in Older Adults with Probable Mild Cognitive Impairment and Poor Sleep: A Randomized Clinical Trial

Background:Poor sleep is common among older adults with mild cognitive impairment (MCI) and may contribute to further cognitive decline. Whether multimodal lifestyle intervention that combines bright light therapy (BLT), physical activity (PA), and good sleep hygiene can improve sleep in older adults with MCI and poor sleep is unknown. Objective:To assess the effect of a […]

Publication Date: May 19, 2020

Observation and interview-based diurnal sleepiness inventory for measurement of sleepiness in patients referred for narcolepsy or idiopathic hypersomnia

STUDY OBJECTIVES:First, to determine whether the three-item ODSI (Observation and interview based Diurnal Sleepiness Inventory) measures the degree of excessive daytime sleepiness (EDS) in patients with suspected narcolepsy or idiopathic hypersomnia (IH). Second, to assess the correlation between the ODSI and the Epworth Sleepiness Scale (ESS) as well as objective polysomnographic measurements. Third, to test […]

Publication Date: May 14, 2020

Feasibility of a complex setting for assessing sleep and circadian rhythmicity in a Fragile X cohort

Introduction Sleep, circadian rhythms, (mental) health, and development are assumed to be intertwined. However, differentiated and reliable parameters of sleep and circadian rhythms are particularly difficult to assess for Fragile X (FXS) individuals. As those parameters need to be observed in complex settings, the feasibility of measurements for people with FXS was to be proven. […]

Publication Date: May 14, 2020

Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow-waves and spindles in healthy young adults

Background The rs1344706 polymorphism in ZNF804A is robustly associated with schizophrenia (SZ), yet brain and behavioral phenotypes related to this variant have not been extensively characterized. In turn, SZ is associated with abnormal non-rapid eye movement (NREM) sleep neurophysiology. To examine whether rs1344706 is associated with intermediate neurophysiological traits in the absence of disease, we […]

Publication Date: May 3, 2020

Rest-activity rhythm in breast cancer survivors: an update based on non-parametric indices

Recently we evaluated by actigraphy the rest-activity circadian rhythm (RAR) in breast cancer (BC) survivors at 5 years from primary diagnosis, as well as in a control group with similar age and body mass index (BMI). RAR, analyzed by Cosinor method, resulted significantly different in BC survivors compared to healthy subjects: BC survivors showed lower […]

Publication Date: April 24, 2020

Sleep disturbance in atopic dermatitis: a case–control study using actigraphy and smartphone‐collected questionnaires

No abstract is available for this article.

Publication Date: April 22, 2020

Refining sleep measurement using the Motionwatch8©: How many days of monitoring do we need to get reliable estimates of sleep quality for older adults with Mild Cognitive Impairment?

Background Mild cognitive impairment (MCI) is a transition stage between healthy cognition and dementia, and is linked to poorer sleep. Objective, reliable, and low-burden field methods to measure older adult sleep are also currently needed. The MotionWatch8© (MW8) wrist-worn actigraph provides estimates of sleep with 14 days of observation; however, there may be underlying differences […]

Publication Date: April 3, 2020

Fractal biomarker of activity in patients with bipolar disorder

Background The output of many healthy physiological systems displays fractal fluctuations with self-similar temporal structures. Altered fractal patterns are associated with pathological conditions. There is evidence that patients with bipolar disorder have altered daily behaviors. Methods To test whether fractal patterns in motor activity are altered in patients with bipolar disorder, we analyzed 2-week actigraphy […]

Publication Date: April 1, 2020

Quantifying Habitual Physical Activity and Sedentariness in Older Adults—Different Outcomes of Two Simultaneously Body-Worn Motion Sensor Approaches and a Self-Estimation

Applicable and accurate assessment methods are required for a clinically relevant quantification of habitual physical activity (PA) levels and sedentariness in older adults. The aim of this study is to compare habitual PA and sedentariness, as assessed with (1) a wrist-worn actigraph, (2) a hybrid motion sensor attached to the lower back, and (3) a […]

Publication Date: March 28, 2020

Daily energy balance and eating behaviour during a 14-day cold weather expedition in Greenland

We assessed energy compensation, appetite and reward value of foods during a 14-day military expedition in Greenland realized by 12 male French soldiers during which energy compensation was optimized by providing them with easy-to-eat palatable foods in excess. Although daily energy expenditure (estimated by accelerometry) stayed relatively constant throughout the expedition (15 ± 9 MJ.d-1), […]

Publication Date: March 18, 2020

Napping in high-performance athletes: sleepiness or sleepability?

Daytime napping is a common practice in high-performance athletes, and is widely assumed to reflect sleepiness arising from sports-related sleep debt. The possibility that athlete naps may also be indicative of ‘sleepability’, a capacity to nap on demand that is only weakly related to homeostatic sleep pressure, has not previously been tested. The present study […]

Publication Date: March 16, 2020

Building a device-free system to prevent fractures in older people with musculoskeletal ambulatory disability symptom complex

This study aimed to measure the physical ability to cope with daily life and perceptions of older people at high risk of sarcopenia. We surveyed parameters to predict the risk of sarcopenia and factors worsening the condition. We used a pretest among five participants to check the relevance and validation of measures for (1) physical […]

Publication Date: March 15, 2020

Prospective association between suicide cognitions and emotional responses to a laboratory stressor: The mediating role of nightly subjective sleep quality

Background Sleep is a reliable correlate of suicidal thoughts and behaviors (STBs), yet few studies have directly examined negative affect in the context of this association. The present study combined daily experience methods with a laboratory paradigm to investigate suicide cognitions as a predictor of emotional responses to environmental stressors, and tested the role of […]

Publication Date: March 15, 2020

Sleep and intrusive memories immediately after a traumatic event in emergency department patients

Study objectives Intrusive memories of psychological trauma are a core clinical feature of posttraumatic stress disorder (PTSD), and in the early period post-trauma may be a potential target for early intervention. Disrupted sleep in the weeks post-trauma is associated with later PTSD. The impact of sleep and intrusive memories immediately post-trauma, and their relation to […]

Publication Date: March 5, 2020

Acupuncture for insomnia with short sleep duration: protocol for a randomised controlled trial

Introduction Insomnia with short sleep duration has a more serious negative impact on patient health. The existing literature suggests that medication therapy is more effective for this phenotype of insomnia compared with cognitive–behavioural therapy. However, the potential side effects of hypnotic medications hinder their clinical application. Acupuncture has been widely used in the treatment of […]

Publication Date: March 1, 2020

Primary care treatment of insomnia: study protocol for a pragmatic, multicentre, randomised controlled trial comparing nurse-delivered sleep restriction therapy to sleep hygiene (the HABIT trial)

Introduction Insomnia is a prevalent sleep disorder that negatively affects quality of life. Multicomponent cognitive-behavioural therapy (CBT) is the recommended treatment but access remains limited, particularly in primary care. Sleep restriction therapy (SRT) is one of the principal active components of CBT and could be delivered by generalist staff in primary care. The aim of […]

Publication Date: March 1, 2020

Chronobiological aspects of sleep restriction modulate subsequent spontaneous physical activity

Purpose First evidence suggests that chronobiological aspects of sleep restriction affect metabolic conditions. Our aim was to investigate whether spontaneous free-living physical activity likewise is affected by chronobiological timing of short sleep. Methods In an experimental randomized, balanced cross-over design, eleven healthy, normal-weight (BMI: 23.9 ± 0.4 kg/m2) men were evaluated. Physical activity was assessed […]

Publication Date: March 1, 2020

Correlates of disrupted sleep–wake variables in patients with advanced cancer

Objectives High rates of sleep difficulties have been found in patients with advanced cancer. However, not much is known about factors that are associated with sleep impairments in this population and that could constitute their potential risk factors or consequences. This study conducted in patients with cancer receiving palliative care aimed to evaluate the relationships […]

Publication Date: February 19, 2020

Sleep disruption after brain injury is associated with worse motor outcomes and slower functional recovery

Background and Aims: Sleep is important for consolidation of motor learning, but brain injury may affect sleep continuity and therefore rehabilitation outcomes. This study aims to assess the relationship between sleep quality and motor recovery in brain injury patients receiving inpatient rehabilitation. Methods: 59 patients with brain injury were recruited from two specialist inpatient rehabilitation […]

Publication Date: February 18, 2020

Scheduled afternoon–evening sleep leads to better night shift performance in older adults

Objectives This study investigated whether an intervention designed to reduce homeostatic sleep pressure would improve night shift performance and alertness in older adults. Methods Non-shift workers aged 57.9±4.6 (mean±SD) worked four day (07:00–15:00) and four night shifts (23:00–07:00). Two intervention groups were instructed to remain awake until ~13:00 after each night shift: the sleep timing group (ST; […]

Publication Date: February 13, 2020

Sleep-Wake Cycle in Alzheimer’s Disease Is Associated with Tau Pathology and Orexin Dysregulation

Background:Alzheimer’s disease (AD) is the most common form of dementia. It is mainly characterized by a progressive deterioration of cognition, but sleep-wake cycle disturbances frequently occur. Irregular sleep-wake cycle, insomnia, and daytime napping usually occur in patients with AD in the course of the disease. Objective:The aim of the present study was to verify the […]

Publication Date: February 10, 2020

Improving symptom burden in adults with persistent post-concussive symptoms: a randomized aerobic exercise trial protocol

Background Persistent post-concussive symptoms (PPCS) affect up to 30% of individuals following mild traumatic brain injury. PPCS frequently includes exercise intolerance. Sub-symptom threshold aerobic exercise has been proposed as a treatment option for symptom burden and exercise intolerance in this population. The primary aim of this study is to evaluate whether a progressive, sub-symptom threshold […]

Publication Date: February 5, 2020

Implementing a hybrid cognitive-behavioural therapy for pain-related insomnia in primary care: Lessons learned from a mixed-methods feasibility study

Objectives To test the feasibility of implementing a brief but intensive hybrid cognitive behavioural therapy (Hybrid CBT) for pain-related insomnia. Design Mixed-methods, with qualitative process evaluation on a two-arm randomised controlled feasibility trial. Setting Primary care. Participants Twenty-five adult patients with chronic pain and insomnia. Intervention Hybrid CBT or self-help control intervention. Primary and secondary outcome measures Primary outcomes measures were […]

Publication Date: February 1, 2020

Transitions in Depression (TRANS-ID) Recovery: Study protocol for a repeated intensive longitudinal n= 1 study design to search for personalized early warning signals of critical transitions towards improvement in depression

The Transitions in Depression (TRANS-ID) Recovery study is aimed at gathering intensive longitudinal data in a group of depressed patients during psychological therapy. Per person, we gathered between 500-600 momentary measurements of mood (5 times a day, for 4 months) using the Experience Sampling Method (ESM), as well as weekly symptom checklists and heart rate […]

Publication Date: February 1, 2020

Disruption in daily eating-fasting and activity-rest cycles in Indian adolescents attending school.

A lifestyle with erratic eating patterns and habits predisposes youngsters to obesity. Through a two-phase feasibility study among Indian students living in the Delhi area, we longitudinally examined the following: (1) the daily eating-fasting cycles of students (N = 34) in school and college using smartphones as they transition from high school (aged 13–15 years; […]

Publication Date: January 10, 2020

Reliability and Validity of the Checklist for Function-Focused Care in Service Plans

The purpose of this study was to test the reliability and validity of the Checklist for Function-Focused Care in Service Plans. Function-focused care is a care approach that optimizes function and physical activity during all care interactions. This study used baseline data from the first cohort of the study titled Dissemination and Implementation of Function-Focused […]

Publication Date: January 1, 2020

Insomnia does not affect heart rate changes when young adults watch humorous films: An exploratory study

Emotional reactivity in insomnia is affected both subjectively and on a physiological level for negative emotional material, but little is known about reactions to positive stimuli. We here investigated whether in younger adult insomnia patients, presentation of short humorous films would lead to heart rate decreases during and after film viewing, as compared to heart […]

Publication Date: December 23, 2019

Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease

Background Melanopsin-expressing retinal ganglion cells (mRGCs), intrinsically photosensitive RGCs, mediate the light-based pupil response and the light entrainment of the body’s circadian rhythms through their connection to the pretectal nucleus and hypothalamus, respectively. Increased awareness of circadian rhythm dysfunction in neurological conditions including Alzheimer’s disease (AD), has led to a wave of research focusing on […]

Publication Date: December 10, 2019

The Teensleep Study: the effectiveness of a school-based sleep education programme at improving early adolescent sleep.

Objective To evaluate the impact of a school-based sleep education programme on adolescent sleep and sleep knowledge. Methods This is the first outcome report on ‘Teensleep’: a novel, teacher-led programme, comprising ten lessons that can be delivered flexibly. Students in Year 10 (n = 1504; mean age = 14.14 ± 0.35 years) from ten UK […]

Publication Date: December 7, 2019

The impact of physical activity and function on falls in assisted living residents

The purpose of this study was to describe physical activity and function of older adults in assisted living communities and test the association between moderate and vigorous activity and falls. This study used baseline data from 393 participants from the first two cohorts in the Function-Focused Care in Assisted Living Using the Evidence Integration Triangle […]

Publication Date: December 1, 2019

Delayed sleep in winter related to natural daylight exposure among arctic day workers

Natural daylight exposures in arctic regions vary substantially across seasons. Negative consequences have been observed in self-reports of sleep and daytime functions during the winter but have rarely been studied in detail. The focus of the present study set out to investigate sleep seasonality among indoor workers using objective and subjective measures. Sleep seasonality among […]

Publication Date: November 30, 2019

Sleepiness as motivation: a potential mechanism for how sleep deprivation affects behavior

Publication Date: November 29, 2019

Block the light and sleep well: Evening blue light filtration as a part of cognitive behavioral therapy for insomnia

The objective of the present study was to assess the effect of combining CBT-I with wearing blue-light blocking glasses 90 min prior to bedtime on subjective and objective sleep parameters and daily symptoms (anxiety, depression, hyperarousal). Thirty patients (mean age 48.1 ± 16.13 years, range 21–71, 15 men/15 women) completed a CBT-I group therapy program, […]

Publication Date: November 22, 2019

Smart Rehabilitation for Neuro-Disability: A Review

Neurological disorders are increasing globally due to various factors such as change in lifestyle patterns as well as personal and professional stress. Scientists belonging to various research and development organizations from a variety of disciplines are working together to invent new rehabilitation devices. Emerging trends in electronics and information technology-enabled devices provide a platform for […]

Publication Date: November 20, 2019

Sleep-wake disorders in Alzheimer’s disease: further genetic analyses in relation to objective sleep measures

This paper presents updated analyses on the genetic associations of sleep disruption in individuals with Alzheimer’s disease (AD). We published previously a study of the association between single nucleotide polymorphisms (SNPs) found in eight genes related to circadian rhythms and objective measures of sleep-wake disturbances in 124 individuals with AD. Here, we present new relevant […]

Publication Date: November 19, 2019

Sleep quality and clinical and psychological manifestations in women with mild systemic lupus erythematosus activity compared to women with fibromyalgia: A preliminary study

Objectives: This study analyzed sleep quality in fibromyalgia (FM) and systemic lupus erythematosus (SLE) and explored its relationship with other clinical and psychological manifestations. Methods: Twenty women with FM, 19 women with SLE and 22 healthy women participated in the study. Subjective sleep quality, fatigue, pain, depression and anxiety were evaluated with self-reports, and objective […]

Publication Date: November 14, 2019

Dynamic metabolic changes in the human thalamus at the transition from waking to sleep-insights from simultaneous MR spectroscopy and polysomnography

An important contribution of the thalamus to the transition from wakefulness to sleep is a consistent finding in animal studies. In humans, only little is currently known about the specific role of the thalamus in regulating wake-sleep transitions. Although changes in thalamic blood flow and activity have been reported, the underlying molecular mechanisms have not […]

Publication Date: October 30, 2019

Gender differences in function, physical activity, falls, medication use, and life satisfaction among residents in assisted living settings

The purpose of the current study was to test for gender differences among residents living in assisted living settings. This was a secondary data analysis using data from the first 64 facilities participating in the ongoing Function Focused Care for Assisted Living study using the Evidence Integration Triangle (FFC-AL-EIT). A total of 593 residents were […]

Publication Date: October 9, 2019

The Effect of a Common Daily Schedule on Human Circadian Rhythms During the Polar Day in Svalbard: A Field Study

All Arctic visitors have to deal with extreme conditions, including a constant high light intensity during the summer season or constant darkness during winter. The light/dark cycle serves as the most potent synchronizing signal for the biological clock, and any Arctic visitor attending those regions during winter or summer would struggle with the absence of […]

Publication Date: October 9, 2019

Variation near MTNR1A associates with early development and interacts with seasons

Melatonin is a circadian regulatory hormone with neuroprotective properties. We have previously demonstrated the association of the genetic variant rs12506228 near the melatonin receptor 1A gene (MTNR1A) with intolerance to shift‐work. Furthermore, this variant has been connected to Alzheimer’s disease. Because of the previously suggested role of melatonin signalling in foetal neurocognitive and sleep development, […]

Publication Date: October 7, 2019

Use of an ANN to Value MTF and Melatonin Effect on ADHD Affected Children

Sleep disorders is one of the most frequent child medical consultation, indeed the rate of children that suffer it in a transitory way is considerably high. Among the most common sleep disorders is named ”children behavioral insomnia”, many different drugs has been used as treatment with poor results with relevant secondary effects. We focus on […]

Publication Date: September 26, 2019

Home Monitoring to Track Activity and Sleep Patterns Among Older Adults: A Feasibility Study

Measuring changes in activity and sleep over time is important for research and practice. While commercially available home monitoring systems passively track these parameters, the feasibility, acceptability, and usefulness of new products need to be evaluated. We tested a commercially available system for providing long-term data on activity and sleep with 10 single women (mean […]

Publication Date: September 13, 2019

A Deep Learning Approach for Sleep-Wake Detection from HRV and Accelerometer Data

Sleep-wake classification is important for measuring the sleep quality. In this paper, we propose a novel deep learning framework for sleep-wake detection by using acceleration and heart rate variability (HRV) data. Firstly, considering the high sampling rate of acceleration data with temporal dependency, we propose a local feature based long short-term memory (LF-LSTM) approach to […]

Publication Date: September 12, 2019

The Relationship between Fatigue and Actigraphy-Derived Sleep and Rest-Activity Patterns in Cancer Survivors

Study Objectives: To investigate objectively-measured sleep and rest-activity cycles in fatigued and non-fatigued cancer survivors. We hypothesized that sleep and rest-activity cycles would be more disturbed in people experiencing clinically-relevant cancer-related fatigue, and that objective measures of sleep would be associated with the severity of fatigue in cancer survivors. Methods: Cancer survivors (n = 87) […]

Publication Date: September 6, 2019

A. Protocol: Using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson’s disease

Background 40% of Parkinson’s Disease (PD) sufferers experience insomnia, impacting health and quality of life for patients and family members, especially carers. There is little evidence that current treatments are effective. Objectives To determine the effectiveness of melatonin in reducing insomnia in 44 individuals with PD using N-of-1 trials. To aggregate group data to arrive […]

Publication Date: September 1, 2019

Eulerian videography technology improves classification of sleep architecture in primates

Sleep is a critically important dimension of primate behavior, ecology, and evolution, yet primate sleep is under-studied because current methods of analyzing sleep are expensive, invasive, and time-consuming. In contrast to electroencephalography (EEG) and actigraphy, videography is a cost-effective and non-invasive method to study sleep architecture in animals. With video data, however, it is challenging […]

Publication Date: August 27, 2019

LoRa Evaluation in Mobility Conditions for a Connected Smart Shoe Measuring Physical Activity

A strong and positive association between increased levels of physical activity, exercise participation and improved health in older adults emerges from research studies. It is consequently relevant to measure not only the amount of physical exercise performed during planned sessions, but also the level of activity all over the daytime. This paper presents a wearable […]

Publication Date: August 19, 2019

A 6-day combined wake and light therapy trial for unipolar depression

Background There are a dozen studies on double or triple chronotherapy in depression (sleep deprivation [wake therapy] + light therapy + sleep advance/stabilization). We investigated efficacy and feasibility of a modified triple chronotherapy protocol. Methods Thirty-five hospitalized patients with moderately severe non-seasonal depressive disorder, mostly free from antidepressants, underwent a 6-day protocol consisting of partial sleep deprivation late in […]

Publication Date: August 19, 2019

Revisiting the MotionWatch 8: Calibrating cut-points for measuring physical activity and sedentary behaviour among adults with stroke

Reduced moderate-to-vigorous physical activity (MVPA) and increased sedentary behavior (SB) are common following stroke, which can limit stroke recovery and contribute to greater cognitive decline. Hence, the MVPA and SB of adults with stroke should be measured concurrently using objective methods. One currently available method for objectively measuring MVPA and SB is the MotionWatch8© (MW8). […]

Publication Date: August 5, 2019

Validity of actigraphy compared to polysomnography for sleep assessment in children with autism spectrum disorder

Actigraphy (ACT) is a non-invasive objective assessment tool for the study of sleep–wake rhythms. It is of particular interest in children with autism spectrum disorder (ASD), as sleep disorders are highly prevalent and have a significant impact on both cognitive and behavioral functions. As polysomnography (PSG), the gold standard for the assessment of sleep, is […]

Publication Date: August 2, 2019

Can psychomotor disturbance predict ECT outcome in depression?

Psychomotor symptoms are core features of melancholic depression. This study investigates whether psychomotor disturbance predicts the outcome of electroconvulsive therapy (ECT) and how the treatment modulates psychomotor disturbance. In 73 adults suffering from major depressive disorder psychomotor functioning was evaluated before, during and after ECT using the observer-rated CORE measure and objective measures including accelerometry […]

Publication Date: July 29, 2019

Prebiotic supplementation does not affect reading and cognitive performance in children: A randomised placebo-controlled study

Based on the emerging interest in the effects of gut microbiota on cognition, this proof-of-concept study assessed how children aged 7 to 9 with low reading scores responded to the ingestion of a 3-month prebiotic supplement versus a placebo. As a secondary aim, the effects of the prebiotic on cognition, sleep, behaviour, mood, anxiety, and […]

Publication Date: July 25, 2019

Differences in dietary niche and foraging behavior of sympatric mule and white‐tailed deer

Mule (Odocoileus hemionus) and white‐tailed deer (Odocoileus virginianus) are congeneric and share similar life histories, yet their distribution is segregated across much of North America. Extensive research on both species within and outside their zone of co‐occurrence has not fully explained these distribution patterns, especially the potential role of diet and foraging behavior. Therefore, we […]

Publication Date: July 23, 2019

Neurobiological Basis of Sleep and Wake Dysfunction In AD and Other Tauopathies: The Role of the Neuromodulatory System

Wake, sleep and circadian disturbances are common occurrences in Alzheimer’ disease (AD) and other tauopathies often preceding disease-defining symptoms. Clinical data point to a divergent sleep-wake behavior profiles among tauopathies which probably reflects their differential pattern of neuronal vulnerability and spread and thus, have implications for developing symptomatic and disease-modifying treatments. Although some aspects of […]

Publication Date: July 14, 2019

Actigraphic Screening for Rapid Eye Movement Sleep Behavior Disorder

Background: The patients suffering of the rapid eye movement sleep behavior disorder (RBD) are in high risk of developing a neurodegenerative disorder, most frequently from the group of alpha-synucleinopathies, such as Parkinson’s disease (PD), Dementia with Lewy Bodies (DLB) or multiple system atrophy (MSA). The definitive diagnosis of RBD is based on polysomnographic investigation. Actigraphy […]

Publication Date: July 14, 2019

Response to Treatment With Lemborexant: Subjects With Irregular Sleep-Wake Rhythm Disorder and Alzheimer’s Disease Dementia

Irregular sleep-wake rhythm disorder (ISWRD) is a circadian rhythm sleep disorder, distinct from insomnia, which is characterized by the irregular distribution of sleep bouts across the 24-hour period rather than consolidated sleep at night. ISWRD symptoms are common in patients with Alzheimer’s disease dementia (AD-D). Pathology of ISWRD includes disturbed circadian rhythmicity, neuronal loss in […]

Publication Date: July 14, 2019

Decreased need for sleep as an endophenotype of bipolar disorder: an actigraphy study

Reports of subjective sleep impairments have been replicated in adults with bipolar disorder (BD), young BD patients, and even children of parents with BD. Furthermore, circadian rhythm alterations are a core feature of BD. Despite the impairment in circadian rhythms and altered sleep included in various heuristic developmental models of BD, thus far, biomarkers have […]

Publication Date: July 1, 2019

Sleep Quality and Quantity of International Rugby Sevens Players During Pre-season

The aim of this study was to investigate the influence of training load on objective and subjective sleep measures among elite rugby sevens players during pre-season. Nine international male rugby sevens players participated in this study. Actigraphic and subjective sleep assessment were performed on a daily basis to measure sleep parameters. Training load was measured […]

Publication Date: July 1, 2019

Effects of a dawn-dusk simulation on circadian rest-activity cycles, sleep, mood and well-being in dementia patients

Light is the most powerful “zeitgeber” signal to synchronize circadian sleep-wake cycles. In dementia, these rhythms are often fragmented — probably due to loss of neuronal function of the suprachiasmatic nuclei (the biological “master clock” in the brain) and/or weakness of external zeitgebers. We investigated the effects of a prototype dawn-dusk simulator (DDS) on circadian […]

Publication Date: June 25, 2019

Impact of Function Focused Care and Physical Activity on Falls in Assisted Living Residents

Background There continues to be a belief among nurses, patients, and families that physical activity increases the risk of falling. Purpose The purpose of this study was to test the hypothesis that controlling for age, function, cognition, medication use, gender, comorbidities, and cognition, residents who are exposed to Function Focused Care for Assisted Living (FFC-AL-EIT) […]

Publication Date: June 21, 2019

Visual imagery and visual perception induce similar changes in occipital slow waves of sleep

Publication Date: June 10, 2019

Rest-activity circadian rhythm in breast cancer survivors at 5 years after the primary diagnosis

Rest-activity circadian rhythm (RAR) is a marker of the circadian timing system. Particular attention has been given to RAR characteristics in cancer diseases. Specifically, alterations of RAR parameters have been found, at different stages of clinical pathway, in breast cancer (BC) patients. No studies to date have analyzed RAR alterations in breast cancer survivors several […]

Publication Date: June 10, 2019

Beyond the low frequency fluctuations morning and evening differences in human brain

Human performance, alertness, and most biological functions express rhythmic fluctuations across a 24-hour-period. This phenomenon is believed to originate from differences in both circadian and homeostatic sleep-wake regulatory processes. Interactions between these processes result in time-of-day modulations of behavioral performance as well as brain activity patterns. Although the basic mechanism of the 24-hour clock is […]

Publication Date: June 6, 2019

Living in Biological Darkness: Objective Sleepiness and the Pupillary Light Responses Are Affected by Different Metameric Lighting Conditions during Daytime

Nighttime melatonin suppression is the most commonly used method to indirectly quantify acute nonvisual light effects. Since light is the principal zeitgeber in humans, there is a need to assess its strength during daytime as well. This is especially important since humans evolved under natural daylight but now often spend their time indoors under artificial […]

Publication Date: June 2, 2019

Who benefits most? Towards accurate prediction of electroconvulsive therapy outcome

Please consult pdf.

Publication Date: June 1, 2019

The Role of Exercise and Age on Vitamin D Metabolism

Please consult pdf.

Publication Date: June 1, 2019

Light affects heart rate’s 24‐h rhythmicity in intensive care unit patients: an observational study

Background Intensive care unit (ICU) patients experience two affronts to normal 24‐h rhythms: largely internal events such as medication and external factors such as light, noise and nursing interventions. Aims and objectives We investigated the impact of light variance within an ICU on 24‐h rhythmicity of three key physiological parameters: heart rate (HR), mean arterial […]

Publication Date: May 14, 2019

Ethnic differences in intrahepatic lipid and its association with hepatic insulin sensitivity and insulin clearance between men of Black and White ethnicity with early type 2 diabetes.

Intrahepatic lipid (IHL) is linked with reduced hepatic insulin sensitivity and insulin clearance. Despite their high risk for type 2 diabetes (T2D), there have been limited investigations of these relationships in black populations. We investigated these relationships in 18 white European (WE) and 18 black West African (BWA) men with T2D <5 years. They underwent magnetic […]

Publication Date: May 10, 2019

Sleep influences cognitive performance in lemurs

Primates spend almost half their lives asleep, yet little is known about how sleep influences their waking cognition. We hypothesized that diurnal and cathemeral lemurs differ in their need for consistent, non-segmented sleep for next-day cognitive function—including long-term memory consolidation, self-control, foraging efficiency, and sociality. Specifically, we expected that strictly diurnal Propithecus is more reliant […]

Publication Date: May 1, 2019

Testing of the Function Focused Environment Assessment and the Function Focused Policy Assessment in Assisted Living.

This study tested two new instruments, the Function Focused Environment Assessment (FF-EA) and the Function Focused Policy Assessment (FF-PA). The measures were developed for clinical evaluation of assisted living (AL) settings to help optimize function and physical activity among residents. In total, 106 AL settings and 242 residents were included. There was evidence of item […]

Publication Date: April 25, 2019

Pregnancy Induces an Earlier Chronotype in Both Mice and Women

Daily rhythms generated by endogenous circadian mechanisms and synchronized to the light-dark cycle have been implicated in the timing of birth in a wide variety of species. Although chronodisruption (e.g., shift work or clock gene mutations) is associated with poor reproductive outcomes, little is known about circadian timing during pregnancy. This study tested whether daily […]

Publication Date: April 24, 2019

The effect of sleep deprivation on objective and subjective measures of facial appearance

The faces of people who are sleep deprived are perceived by others as looking paler, less healthy and less attractive compared to when well rested. However, there is little research using objective measures to investigate sleep‐loss‐related changes in facial appearance. We aimed to assess the effects of sleep deprivation on skin colour, eye openness, mouth […]

Publication Date: April 21, 2019

The effects of brief chat-based and face-to-face psychotherapy for insomnia: A randomized waiting list controlled trial

Background Recent studies have directly compared the effects of Internet-based self-help interventions with face-to-face (FtF) treatment, but groups may also differ regarding other aspects, aside from the fact that the former is online and the latter offline. Thus, we examined the effects of a brief three-session psychotherapy for insomnia that was delivered FtF or through […]

Publication Date: April 19, 2019

Effects of Blue Filtering Lenses on Sleep and Melatonin Production in Good Sleepers

Produced at night, melatonin is a hormone which regulates endogenous circadian rhythms and is suppressed by bright light exposure. The nighttime use of light-emitting devices has been associated with reduced melatonin production and disturbed sleep. Blue light has the most impact on melatonin production and hence on circadian rhythms. This pilot study evaluated whether a […]

Publication Date: April 1, 2019

Exercise training in patients with a left ventricular assist device (Ex‐VAD): rationale and design of a multicentre, prospective, assessor‐blinded, randomized, controlled trial.

Aims Left ventricular assist device (LVAD) therapy is a promising option for patients with advanced heart failure (HF), refractory to guideline‐mandated medical treatment either as a bridge to heart transplantation or as lifelong therapy. Functional capacity improves after LVAD implantation but remains reduced in patients with long‐term LVAD therapy. Exercise training (ET) improves functional capacity […]

Publication Date: March 28, 2019

Time-of-day and days-on-shift predict increased fatigue over two-week offshore day-shifts

Objectives The purpose of this study was to investigate the accumulation of fatigue over a two-week offshore period. In particular, the effects of (1) time-of-day and days-on-shift as well as (2) acute and chronic sleep loss on the rate at which fatigue accumulates were investigated. Methods 42 day-shift offshore workers were examined. Fatigue was measured […]

Publication Date: March 20, 2019

Melatonin, temazepam and placebo in hospitalised older patients with sleeping problems (MATCH): a study protocol of randomised controlled trial

Hospitalised older patients frequently suffer from inadequate sleep, which can lead to patient distress and delayed recovery from acute illness or surgical procedure. Currently, no evidence-based treatments exist for sleeping problems in hospitalised older patients. Benzodiazepines, such as temazepam, are regularly prescribed by physicians, although they have serious side effects; for older patients in particular. […]

Publication Date: March 19, 2019

Treating Disorders of Consciousness with Apomorphine: Protocol for a Double Blind Randomized Controlled Trial using Multimodal Assessments

Background: There are few available therapeutic options to promote recovery among patients with chronic disorders of consciousness (DOC). Among pharmacological treatments, apomorphine, a dopamine agonist, has exhibited promising behavioral effects and safety of use in small-sample pilot studies. The true efficacy of the drug and its neural mechanism are still unclear. Apomorphine may act through […]

Publication Date: March 19, 2019

Long-term reduction of short wavelength light affects sustained attention and visuospatial working memory

The short wavelength, i.e. blue light, is crucial for non-image forming effects such as entrainment of circadian system. Moreover, many studies showed that blue light enhances alertness and performance in cognitive tasks. However, most of scientific reports in this topic is based on studies using short exposure to blue or blue-enriched light and only few […]

Publication Date: March 18, 2019

Hypothalamic‐pituitary‐adrenal axis differentially responses to morning and evening psychological stress in healthy subjects

Aim The hypothalamic‐pituitary‐adrenal (HPA) axis responds to changing environmental demands including psychological stressors. The aim of the present study was to assess whether the time of day effects on the acute response of HPA axis activity to acute psychological stress. Method We studied 27 healthy young subjects. The subjects were participated two experiments as follows. […]

Publication Date: March 3, 2019

Sleep deprivation and its effects on communication during individual and collaborative tasks

Sleep loss has been shown to cause impairments in a number of aspects central for successful communication, ranging from poorer linguistic comprehension to alterations in speech prosody. However, the effect of sleep loss on actual communication is unknown. This study investigated how a night of sleep deprivation affected performance during multiple tasks designed to test […]

Publication Date: February 28, 2019

Sleep and cognitive function in chronic stroke: a comparative cross-sectional study

Poor sleep is common following stroke, limits stroke recovery, and can contribute to further cognitive decline post-stroke. However, it is unclear what aspects of sleep are different in older adults with stroke compared with those without, and whether the relationship between sleep and cognitive function differs by stroke history. We investigated whether older adults with […]

Publication Date: February 26, 2019

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