Publications
CamNtech Research Library
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Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men
A lifestyle characterized by inactivity and a high-calorie diet is a known risk factor for impaired insulin sensitivity and development of Type 2 diabetes mellitus. To investigate possible links, nine young healthy men (24 ± 3 yr; body mass index of 21.6 ± 2.5 kg/m2) completed 14 days of step reduction (10,000 to 1,500 steps/day) […]
Related Product: Actiheart
Publication Date: July 1, 2012
Effect of communicating genetic and phenotypic risk for type 2 diabetes in combination with lifestyle advice on objectively measured physical activity: protocol of a randomised controlled trial
Background Type 2 diabetes (T2D) is associated with increased risk of morbidity and premature mortality. Among those at high risk, incidence can be halved through healthy changes in behaviour. Information about genetic and phenotypic risk of T2D is now widely available. Whether such information motivates behaviour change is unknown. We aim to assess the effects […]
Related Product: Actiheart
Publication Date: June 18, 2012
Effects of everyday life events on glucose, insulin, and glucagon dynamics in continuous subcutaneous insulin infusion–treated type 1 diabetes: collection of clinical data for glucose modeling
Background: In the development of glucose control algorithms, mathematical models of glucose metabolism are useful for conducting simulation studies and making real-time predictions upon which control calculations can be based. To obtain type 1 diabetes (T1D) data for the modeling of glucose metabolism, we designed and conducted a clinical study. Methods: Patients with insulin pump–treated […]
Related Product: Actiheart
Publication Date: February 27, 2012
Physical Activity in Childhood Diabetes
Physical activity is an important part of childhood. It is important for normal childhood development, to maintain healthy bones and body composition, and is useful in developing and maintaining social contacts. Physical activity is no less important for children and young people with diabetes. It is actively encouraged but presents significant challenges for diabetes management […]
Related Product: Actiheart
Publication Date: February 27, 2012
Increased lipolysis but diminished gene expression of lipases in subcutaneous adipose tissue of healthy young males with intrauterine growth retardation
Intrauterine growth retardation (IUGR) is associated with a central fat distribution and risk of developing type 2 diabetes in adults when exposed to a sedentary Western lifestyle. Increased lipolysis is an early defect of metabolism in IUGR subjects, but the sites and molecular mechanisms involved are unknown. Twenty IUGR and 20 control (CON) subjects, aged […]
Related Product: Actiheart
Publication Date: December 1, 2011
Safety and efficacy of 24-h closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes: a randomized crossover case series
OBJECTIVE To evaluate the safety and efficacy of closed-loop insulin delivery in well-controlled pregnant women with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII). RESEARCH DESIGN AND METHODS A total of 12 women with type 1 diabetes (aged 32.9 years, diabetes duration 17.6 years, BMI 27.1 kg/m2, and HbA1c 6.4%) were randomly allocated […]
Related Product: Actiheart
Publication Date: November 21, 2011
Impact of physical inactivity on adipose tissue low-grade inflammation in first-degree relatives of type 2 diabetic patients.
OBJECTIVE First-degree relatives (FDRs) of patients with type 2 diabetes may exhibit a disproportionately elevated risk of developing insulin resistance, obesity, and type 2 diabetes when exposed to physical inactivity, which to some unknown extent may involve low-grade inflammation. We investigated whether subjects who are nonobese FDRs show signs of low-grade inflammation before or after […]
Related Product: Actiheart
Publication Date: October 1, 2011
Endothelial function after 10 days of bed rest in individuals at risk for type 2 diabetes and cardiovascular disease
Physical inactivity is considered to be deleterious to vascular health, and in particular in first-degree relatives to patients with type 2 diabetes (FDR) and persons born with low birth weight (LBW), who may later in life develop cardiovascular disease. A period of imposed physical inactivity could unmask this risk. We hypothesized that the impact of […]
Related Product: Actiheart
Publication Date: July 5, 2011
Mitochondrial dysfunction in patients with primary congenital insulin resistance
Mitochondrial dysfunction is associated with insulin resistance and type 2 diabetes. It has thus been suggested that primary and/or genetic abnormalities in mitochondrial function may lead to accumulation of toxic lipid species in muscle and elsewhere, impairing insulin action on glucose metabolism. Alternatively, however, defects in insulin signaling may be primary events that result in […]
Related Product: Actiheart
Publication Date: May 9, 2011
Insulin detemir reduces weight gain as a result of reduced food intake in patients with type 1 diabetes
OBJECTIVE Insulin detemir lacks the usual propensity for insulin to cause weight gain. We investigated whether this effect was a result of reduced energy intake and/or increased energy expenditure. RESEARCH DESIGN AND METHODS A 32-week, randomized crossover design trial was undertaken in 23 patients with type 1 diabetes. Patients on a basal-bolus regimen (with insulin […]
Related Product: Actiheart
Publication Date: April 18, 2011
Protocol for the ADDITION-Plus study: a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care
Background The increasing prevalence of type 2 diabetes poses both clinical and public health challenges. Cost-effective approaches to prevent progression of the disease in primary care are needed. Evidence suggests that intensive multifactorial interventions including medication and behaviour change can significantly reduce cardiovascular morbidity and mortality among patients with established type 2 diabetes, and that […]
Related Product: Actiheart
Publication Date: April 4, 2011
Impact of physical inactivity on subcutaneous adipose tissue metabolism in healthy young male offspring of patients with type 2 diabetes
OBJECTIVE Physical inactivity is a risk factor for type 2 diabetes and may be more detrimental in first-degree relative (FDR) subjects, unmasking underlying defects of metabolism. Using a positive family history of type 2 diabetes as a marker of increased genetic risk, the aim of this study was to investigate the impact of physical inactivity […]
Related Product: Actiheart
Publication Date: October 27, 2010
A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity
US adults take between ∼2,000 and ∼12,000 steps per day, a wide range of ambulatory activity that at the low range could increase risk for developing chronic metabolic diseases. Dramatic reductions in physical activity induce insulin resistance; however, it is uncertain if and how low ambulatory activity would influence peripheral insulin sensitivity. We aimed to […]
Related Product: Actiheart
Publication Date: May 1, 2010
Effect of 10 days of bedrest on metabolic and vascular insulin action: a study in individuals at risk for type 2 diabetes
Physical inactivity is a known risk factor for type 2 diabetes. We studied whole body and forearm insulin sensitivity in subjects at increased risk for type 2 diabetes [persons with low birth weight (LBW group; n = 20) and first-degree relatives to type 2 diabetic patients (FDR group; n = 13)] as well as a […]
Related Product: Actiheart
Publication Date: April 1, 2010
Time course of changes in inflammatory markers during a 6-mo exercise intervention in sedentary middle-aged men: a randomized-controlled trial.
Regular exercise may improve systemic markers of chronic inflammation, but direct evidence and dose-response information is lacking. The objective of this study was to examine the effect and time course of changes in markers of chronic inflammation in response to progressive exercise training (and subsequent detraining). Forty-one sedentary men 45–64 yr of age completed either […]
Related Product: Actiheart
Publication Date: April 1, 2010
Prevalence of glucose intolerance and associated risk factors in rural and urban populations of different ethnic groups in Kenya
Objective To assess the prevalence of glucose intolerance in rural and urban Kenyan populations and in different ethnic groups. Further, to identify associations between lifestyle risk factors and glucose intolerance. Research design and methods A cross-sectional study included an opportunity sample of Luo, Kamba, Maasai, and an ethnically mixed group from rural and urban Kenya. […]
Related Product: Actiheart
Publication Date: April 9, 2009
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