Introduction
Clinical observations are routinely used to address drug-induced behavioural changes in dogs. To deal with the limitations of this methodology, we evaluated Actiwatch-Mini® as a tool to monitor continuously locomotor activity in dogs and to provide objective parameters that could be linked to behavioural changes after compound administration.

Methods
Eight Beagles were equipped with Actiwatch-Mini®. As a reference drug, a PDE2-inhibitor was administered daily for six days at doses known to cause minor or severe behavioural changes.

Results
While traditional observation showed no behavioural changes – except sedation – dogs receiving 0.5 mg/kg/day, showed significant increases in % immobile time (+15.8%) and mean length of immobile phases (+1.2 min) but no change in number of immobile phases (+2.2). At 1 mg/kg/day, light to severe changes in behaviour were present. Actiwatch-Mini® recorded an increase in mean length of immobile phases (+1.9 min) and a decrease in mean number of immobile phases (−7.4) in the first four hours after each dosing while total % immobile time was not significantly increased (+4.9%).

Discussion
Actiwatch-Mini® was able to detect changes in immobility parameters in dogs dosed with a PDE2-inhibitor while no or only minor behavioural changes were observed. The system can be used for continuously monitoring the activity of dogs, to provide objective scores for evaluation of activity. It provides an inexpensive and low labour-intensive method for detecting changes in activity and possible early indications of drug-induced behavioural changes.

Direct Link: https://doi.org/10.1016/j.vascn.2020.106896

Journal: Journal of Pharmacological and Toxicological Methods. 2020 Jul 3:106896

Keywords: Behaviour, clinical observation, dogs, Physical Activity, veterinary,

Applications: Veterinary,

CamNtech Reference: AM20002

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