Schizophrenia is a complex, polygenic disorder for which over 100 genetic variants have been identified that correlate with diagnosis. However, the biological mechanisms underpinning the different symptom clusters remain undefined. The rs1344706 single nucleotide polymorphism within ZNF804A was among the first genetic variants found to be associated with schizophrenia. Previously, neuroimaging and cognitive studies have revealed several associations between rs1344706 and brain structure and function. The aim of this study is to use a recall-by-genotype (RBG) design to investigate the biological basis for the association of ZNF804A variants with schizophrenia. A RBG study, implemented in a population cohort, will be used to evaluate the impact of genetic variation at rs1344706 on sleep neurophysiology and procedural memory consolidation in healthy participants.

Direct Link: https://doi.org/10.1186/s12881-015-0244-4

Journal: BMC medical genetics. 2015 Dec 1;16(1):96.

Keywords: ALSPAC, memory, schizophrenia, Sleep, spindles, ZNF804A,

Applications: Sleep,

CamNtech Reference: M15002

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