Background
Incident atherothrombotic disease is predicted by leukocyte telomere length, a marker of biological age, and hemostatic factor levels, indicating a hypercoagulable state. We hypothesized that shorter telomeres are associated with elevated circulating levels of hemostatic factors.

Methods
We examined 171 South African (black) and 182 Caucasian (white) schoolteachers (mean age ± standard deviation, 48.5 ± 9.0 years; 50.4% women). Levels of fibrinogen, von Willebrand factor antigen (VWF:Ag), D‐dimer and plasminogen activator inhibitor‐1 antigen (PAI‐1:Ag) were measured in plasma, and values were log‐transformed before analysis. Relative average telomere length (content of telomere PCR product/content of human β‐globin PCR product ratio, i.e. telomere/single‐copy gene ratio) was assessed with multiplex quantitative real‐time PCRs. Multivariate analyses included demographics, metabolic factors, health behavior, and medication.

Results
Africans had shorter mean telomere length (0.82, 95% confidence interval [CI] 0.79–0.86 vs. 1.07, 95% CI 1.04–1.10) and higher fibrinogen (B = 0.085, 95% CI 0.061–0.109) and PAI‐1:Ag (B = 0.255, 95% CI 0.206–0.303) levels, but lower VWF:Ag levels (B = − 0.059, 95% CI − 0.089 to − 0.028), than Caucasians. Shorter telomeres were associated with higher fibrinogen (B = − 0.045, 95% CI − 0.088 to − 0.001), VWF:Ag (B = − 0.137, 95% CI − 0.193 to − 0.081) and D‐dimer (B = − 0.201, 95% CI − 0.377 to − 0.025) levels, conditional on ethnicity. An interaction emerged between ethnicity and telomere length for VWF:Ag level; that is, shorter telomeres were associated with higher VWF:Ag levels in Caucasians (B = − 0.170, 95% CI − 0.232 to − 0.108) but not in Africans.

Conclusions
Shorter telomeres were associated with increased levels of several hemostatic factors after adjustment for confounding variables, whereby ethnicity partially moderated this effect. A relationship between accelerated biological aging and hypercoagulability might contribute to the risk of premature atherothrombotic events.

Direct Link: https://doi.org/10.1111/jth.12733

Journal: Journal of Thrombosis and Haemostasis. 2014 Dec;12(12):1975-85

Keywords: blood coagulation, cardiovascular disease, energy expenditure, ethnicity, fibrinolysis, genetics, telomere,

Applications: Energy Expenditure,

CamNtech Reference: AH14058

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