Abdominal fat accumulation after menopause is associated with low‐grade inflammation and increased risk of metabolic disorders. Effective long‐term lifestyle treatment is therefore needed.

Seventy healthy postmenopausal women (age 60 ± 5.6 years) with BMI 32.5 ± 5.5 were randomized to a Paleolithic‐type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation‐related parameters.

Android fat decreased significantly more in the PD group (P  = 0.009) during the first 6 months with weight maintenance at 24 months in both groups. Long‐term significant effects (P  < 0.001) on adipose gene expression were found for toll‐like receptor 4 (decreased at 24 months) and macrophage migration inhibitory factor (increased at 24 months) in both groups. Serum interleukin 6 (IL‐6) and tumor necrosis factor α levels were decreased at 24 months in both groups (P  < 0.001) with a significant diet‐by‐time interaction for serum IL‐6 (P  = 0.022). High‐sensitivity C‐reactive protein was decreased in the PD group at 24 months (P  = 0.001).

A reduction of abdominal obesity in postmenopausal women is linked to specific changes in inflammation‐related adipose gene expression.

Direct Link: https://doi.org/10.1002/oby.21815

Journal: Obesity. 2017 May;25(5):892-900

Keywords: diet, inflammation, intervention, obesity, Physical Activity, postmenopausal women,

Applications: Physical Activity,

CamNtech Reference: AH17034

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