Objective In Alzheimer’s disease (AD), the presence of circadian dysfunction is well-known and may occur early in the disease course. The melanopsin retinal ganglion cell (mRGC) system may play a relevant role in contributing to circadian dysfunction. In this...
Antidepressant discontinuation increases the risk of experiencing depressive symptoms. In a repeated single-subject design, we tested whether transitions in depression were preceded by increases in actigraphy-based critical-slowing-down-based early-warning signals...
BACKGROUND Although the relationships among physical disability, mood disorders, and pain are well described in multiple sclerosis (MS), little is known about whether those symptoms are associated with sleep disturbances. METHODS Forty-six patients with MS...
Actigraphy (ACTG) is easy to use and has proved reliable in non-critical populations of patients. It has been used to track circadian rest-activity cycles and to identify states of wakefulness and sleep [1]. A more recent study has found that ACTG have a moderate...
Objective This study aimed to assess the sleep-wake pattern in patients with epilepsy compared to controls. Methods Patients with epilepsy and controls underwent a 14-day actigraphic recording to evaluate the rest-activity cycle. A sleep medicine interview was...
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