Sleep-wake rhythm disturbances in patients with Alzheimer’s disease (AD) make a strong demand on caregivers and are among the most important reasons for institutionalization. Several previous studies reported that the disturbances improve with increased...
Nightly restlessness in patients with Alzheimer’s disease (AD) is probably due to a disorder of circadian rhythms. Transcutaneous electrical nerve stimulation (TENS) was previously reported to increase the strength of coupling of the circadian rest–activity rhythm to...
Light is known to be an important modulator of circadian rhythms. We tested the hypothesis that an enduring increase in the daytime environmental illumination level improves restactivity rhythm disturbances in demented patients. Actigraphy was performed before,...
In old age, the circadian timing system loses optimal functioning. This process is even accelerated in Alzheimer’s disease. Because pharmacological treatment of day-night rhythm disturbances usually is not very effective and may have considerable side effects,...
Previous studies showed circadian rhythm disturbances in patients with Alzheimer’s disease. Rest-activity rhythm disturbances manifest themselves through a fragmentation of the rhythm, a weak coupling with Zeitgebers, and high levels of activity during the...
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